Pathophysiology and treatment of Paget"s disease of bone

  • 298 Pages
  • 2.90 MB
  • English
Martin Dunitz , London
Osteitis defor
StatementJohn A. Kanis.
SeriesMetabolic bone disease
LC ClassificationsRC931.O65 K35 1991
The Physical Object
Paginationx, 298 p., [8] p. of plates :
ID Numbers
Open LibraryOL20668016M
ISBN 100948269731

Pathophysiology and Treatment of Paget's Disease of Bone 2nd Edition by Kanis, John A () Hardcover $ In Stock. Enter your mobile number or email address below and we'll send you a link to download the free Kindle App. Then you can start reading Kindle books on your smartphone, tablet, or computer - no Kindle device required.

Cited by: Paget’s disease of bone is a chronic (long-lasting) disorder that causes bones to grow larger and become weaker than normal. With treatment, many people can manage their symptoms, improve pain, and control the effects of the disease.

This article will review the epidemiology, pathology, etiology, pathophysiology, diagnosis, and medical management of Paget's disease of bone.

Epidemiology Paget's disease of bone, or osteitis deformans, is a common geriatric problem, occurring in 3% to 4% of the population over 50 years of age. 1 It is slightly more common in men. 2 The. Doctors don't really know what causes Paget's disease. It may be a viral infection of the bone, or it could be caused by something in the environment.

In about 15% to 30% of cases, there's a. Paget disease is a localized disorder of bone remodeling that typically begins with excessive bone resorption followed by an increase in bone formation.

[] This osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more.

Paget's disease can be associated with several complications including deafness, pathological fracture, secondary osteoarthritis, cranial nerve compression syndromes, and spinal stenosis ().Although many of these conditions are also common in elderly patients without Paget's disease of bone, epidemiological studies have shown that patients with this disease are 31-times more likely to Cited by: Paget’s disease of bone is named after Sir James Paget, who first identified the condition in the 19th century.

It affects the way your bone develops and renews itself, causing it. Paget’s disease is the second most common type of bone disease after osteoporosis.

It is a disorder of the bone remodeling process, in which the body absorbs old bone and forms abnormal new bone. Kanis J. Pathophysiology and treatment of Paget's disease of bone. ; Fogelman I, ed. London: Martin Dunitz Ltd. Haddaway MJ, Davie MW, McCall IW, Howdle S. Effect of age and gender on the number and distribution of sites in Paget’s disease of by: is a rapid access, point-of-care medical reference for primary care and emergency clinicians.

Started inthis collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters. Advances in Pathobiology and Management of Paget’s Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget’s disease.

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It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology.

Treatment for Paget’s disease focuses on alleviating symptoms and reducing bone turnover, with a long-term goal of inducing remission to prevent progression and complications.

5 Both calcitonin and bisphosphonates inhibit osteoclastic bone resorption and may be used to treat Paget’s disease. Analgesics and nonsteroidal anti-inflammatory. Paget’s disease of bone complication. This condition usually progresses slowly in the body.

However, it may cause certain complications such as: Bones may fracture very easily. Deformed bones may lead to excess bleeding during surgeries. It may also cause bow legs. Paget’s Disease as stated is a chronic pathological condition of the bones in which there is a disorder of the normal process of bone remodeling.

Paget’s Disease affects the skeletal bones. Studies estimate that about 1% of population in the United States have Paget’s Disease. Paget's disease of bone (PDB) is a condition of unknown etiology characterized by excessive and abnormal bone remodeling.

It may be localized to one or several skeletal segments. Advances in Pathobiology and Management of Paget's Disease of Bone (ebook) ISBN Additional ISBNs:. The treatment strategies for this condition are: Medication: Medications such as bisphosphonates are used in treating Paget’s disease.

Surgery: Surgical options to treat Paget’s disease include corrective osteotomy for long bone deformity, joint arthroplasty, tumor resection, fracture fixation, and. Paget's Disease of Bone Surgery. When Paget’s disease causes fractures or serious bone deformities, surgical treatment may be necessary.

Fractures from this disease are common in the thigh and shin bones, and surgery involves the insertion of an intramedullary rod into the center of the bone.

Pathophysiology and treatment of Paget's disease of bone. [John A Kanis] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Topics covered in this book include epidemiology, pathophysiology, imaging techniques, biochemical and endocrine aspects, clinical features and complications.

This is known as bone remodeling.

Details Pathophysiology and treatment of Paget"s disease of bone FB2

However, Paget’s disease interferes with this process. Over time, it causes a person’s bones to become weak. Eventually, they may also become misshapen and prone to fractures. While treatment often involves oral medications (known as bisphosphonates), some people fail to obtain relief from them.

Paget’s disease is a chronic condition which interferes with your body’s normal bone remodeling process. Bone remodeling is a process in which new bone tissue gradually replaces old bone tissue.

This relationship is vital to maintain normal calcium levels in our blood. Over time, the disease can cause affected bones to become fragile and misshapen.

What is Paget's disease of bone. Paget's disease of bone is a chronic bone disorder. Normally, there is a process in which your bones break down and then regrow. In Paget's disease, this process is abnormal. There is excessive breakdown and regrowth of bone.

Because the bones regrow too quickly, they are bigger and softer than normal. More Paget's disease of bone animations & videos Research about Paget's disease of bone. Visit our research pages for current research about Paget's disease of bone treatments. Clinical Trials for Paget's disease of bone.

The US based website lists information on both federally and privately supported clinical trials using human volunteers. Get this from a library. Pathophysiology and treatment of Paget's disease of bone. [John A Kanis]. Some patients are asymptomatic but others present with bone pain or other complications such as fracture and deformity.

Major advances have been made in understanding the pathophysiology of Paget’s disease in recent years and highly effective agents are now available with which to suppress the abnormal bone turnover that causes the disease. Paget's disease of bone is a common disease characterised by focal areas of increased bone turnover, affecting one or several bones throughout the skeleton.

Paget's disease is often asymptomatic but can be associated with bone pain and other complications such as osteoarthritis, pathological fracture, bone deformity, deafness, and nerve compression by: Paget's disease of bone is the second most common metabolic bone condition behind osteoporosis, causing accelerated bone growth leading to tumors and increased bleeding from 's disease of bone affects one or more bones in the body.

Treatment with a potent bisphosphonate is indicated in patients with Paget's disease who have symptoms likely to respond to reduced bone turnover at pagetic sites. In asymptomatic patients with active disease at sites susceptible to local progression and late complications, treatment is.

Description Pathophysiology and treatment of Paget"s disease of bone EPUB

Title: Paget’s Disease Of The Bone: Symptoms, Causes, Diagnosis and Treatment (1) 1 Pagets Disease 2 Pagets Disease.

Pagets disease of the bone is a long-term bone disorder resulting in the enlargement and deformation of bones. Pagets disease is the second most common type of bone disorder in the world. The excessive breakdown of tissue due to.

Start studying Paget's Disease of Bone. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. --Possibly some viral infection causes the osteoclasts to go crazy.

Paget's Disease of Bone Treatment. Paget’s disease of the bone occurs when the normal processes of bone breakdown and rebuilding are performing abnormally. As a result, the bones become too .Paget's disease of bone; Other names: osteitis deformans, Paget's disease "This 92 year-old male patient presented for assessment of sudden inability to move half his incidental finding was marked thickening of the diploic space is widened and there are ill-defined sclerotic and lucent areas throughout.

The cortex is thickened and ciation: "Paget" /ˈpædʒɪt/. The treatment of this disorder is discussed elsewhere. (See "Treatment of Paget disease of bone".) EPIDEMIOLOGY. Paget disease of bone (PDB) is a fairly common finding in aging bone, with estimates ranging from to 9 percent in older patients within affected populations ; it is often asymptomatic.

Its onset is typically after with a.